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Working and treatment of Loratadine - Claritin Prescription drug
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| Working and treatment of
Loratadine - Claritin RediTabs |
Loratadine is a drug which is used to in the treatment of seasonal
allergic rhinitis. This drug is similar to cyproheptadine and
azatadine in structure.Loratadine is basically a non-sedating
blocker of H1.According to the tests made Loratidine does not
penetrate through CNS.It also has low affinity for H1 receptors. The
drug has a weak affinity not only for acetylcholine but also for
alpha adrenergic receptors. Loratadine is similar in mechanism with
other H1 blockers. It also competes with free histamine.
The reason for this is its binding with H1 receptors. This is done
in the GI tract, uterus, muscle particularly bronchial or the large
blood vessels.Loratadine has a rapid metabolism of first pass
hepatic. It is also absorbed from the body organ or the
gastrointestinal tract. This drug is bound to the plasma proteins in
the body.Descarboethoxyloratadine or desloratadine is its metabolite
which is active. It binds moderately to the plasma proteins.
The effect of this drug is seen in about one or two hour. The
biological half life of this drug is about eight hours, while its
metabolite’s half life is about twenty eight hours. Some traces of
loratadine which is unmetabolised are found in the urine.Loratadine
when taken with certain other medications show various drug
interactions. The basic function of the drug is to block the action
of the histamine receptors. This in turn prevents or reduces the
reactions of the immune system which plays the role of causing the
allergy symptoms.
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